GH 191AA (Somatropin) Research Peptide

Research Overview

GH 191AA Somatropin is a recombinant human growth hormone (rhGH) consisting of a 191 amino acid single-chain polypeptide that is structurally identical to the growth hormone naturally secreted by the anterior pituitary gland. Manufactured using mammalian or E. coli expression systems and purified by multi-step chromatography, this 22 kDa protein has been one of the most extensively studied molecules in modern endocrinology for over four decades. Researchers use Somatropin to investigate cellular regeneration, somatotropic-axis signaling, and the cascade through the GH receptor that triggers downstream IGF-1 expression in the liver. Beyond its central role in linear growth research, Somatropin is widely used to model lipolysis in adipocytes, protein synthesis in skeletal muscle, glycogenolysis in hepatocytes, and connective-tissue turnover. Investigators also rely on it to explore body composition, bone mineral density, immune competence, and cardiovascular adaptation in animal studies. Because the recombinant molecule mirrors the endogenous hormone exactly, it remains the gold-standard reference compound when researchers benchmark newer GH-axis modulators such as Tesamorelin, Sermorelin, CJC-1295 and Ipamorelin. Its well-characterized half-life, predictable pharmacokinetics and decades of supporting literature make it an indispensable laboratory reagent in growth-factor research.

CAS Number

12629-01-5

Molecular Formula

C990H1528N262O300S7

Molar Mass

22,124 Da

Molecular Sequence

191 amino acid recombinant human growth hormone (single chain polypeptide identical to pituitary hGH)